clinical stage compounds  (TargetMol)

Journal: British Journal of Pharmacology

Article Title: Development of a stretch‐induced neurotrauma model for medium‐throughput screening in vitro : identification of rifampicin as a neuroprotectant

doi: 10.1111/bph.13642

Figure Lengend Snippet: Summary of the clinical libraries included in the composite library used for the screening: The sources of drugs included the IDC, NIH, FDA, USD and Prestwick chemical libraries: a total of 3670 compounds

Article Snippet: Compounds were dissolved at 10 mM in DMSO and dilutions were made either in DMSO or in PBS (pH 7.4) to obtain 0.5% final DMSO concentration used in the screening plates. table ft1 table-wrap mode="anchored" t5 Table 1 caption a7 Compound collection Number of compounds Description Source and link NIH Clinical Collection 450 Compounds that have already been in clinical use or in clinical trials National Institutes of Health www.nihclinicalcollection.com US Drug Collection 1140 Compounds that have reached the stage of clinical trials in the USA Microsource Discovery Systems www.msdiscovery.com International Drug collection 240 Compounds that have reached the stage of clinical trials in other countries Microsource Discovery Systems www.msdiscovery.com New Prestwick Chemical Library 1200 Drugs that are in clinical use Prestwick www.prestwickchemical.com FDA Approved Drug Library 640 Compounds selected from another library of clinically used compounds Enzo Life Sciences www.enzolifesciences.com/BML‐2841/fda‐approved‐drug‐library/ Open in a separate window Summary of the clinical libraries included in the composite library used for the screening: The sources of drugs included the IDC, NIH, FDA, USD and Prestwick chemical libraries: a total of 3670 compounds

Techniques: